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Migraine and magnesium


Wednesday, May 05 2004 - Filed under: General

Migraines seem to be correlated to magnesium deficiency:

From: www.sims.berkeley.edu/~hearst/papers/acl99/acl99-tdm.html
''For example, when investigating causes of migraine headaches, he extracted various pieces of evidence from titles of articles in the biomedical literature. Some of these clues can be paraphrased as follows:

stress is associated with migraines
stress can lead to loss of magnesium
calcium channel blockers prevent some migraines
magnesium is a natural calcium channel blocker
spreading cortical depression (SCD) is implicated in some migraines
high leveles of magnesium inhibit SCD
migraine patients have high platelet aggregability
magnesium can suppress platelet aggregability

These clues suggest that magnesium deficiency may play a role in some kinds of migraine headache; a hypothesis which did not exist in the literature at the time Swanson found these links. The hypothesis has to be tested via non-textual means, but the important point is that a new, potentially plausible medical hypothesis was derived from a combination of text fragments and the explorer's medical expertise. (According to swanson91, subsequent study found support for the magnesium-migraine hypothesis Ramadan et al.1989.)''

Low brain magnesium in migraine, Ramadan 1989.
www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=2584000

Association of headaches and the metals, Donma O, 2002.
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12666820


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