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How sulphur deficiency affects health and detoxification and hormone metabolism
Saturday, February 09 2002 - Filed under: General

I've also been searching for info on sulphur deficiency (which I have)
and I found some very interesting info..

Sulphur is needed to properly detox phenols and amines. Sulphur
transferase depends on sulphur..
Since my sulphur count is very low, I can assume that the sulphur
transferase isn't working ok..

This might cause the night sweats I experienced after eating an apple
(which is high in phenols).
Also I read this:
>Basically autistic children have been found to lack sulphate which is required to form the protective barrier mucin along the inner lining of the intestine. Sulphation also protects the intestinal barrier by making it difficult for bacteria to settle down and colonise.

>Treat any underlying yeast overgrowth because certain bacteria are sulphur reducing thereby depleting the body of needed sulphate.
>

I eat lots of sulphur-containing foods (meats, eggs) and still my
sulphate levels are very low.. This must mean that somehow the foods
are not absorbed OR the cysteine (an amino acid which is the precursor
of sulphate) isn't properly converted into sulphate.

So, this created the conditions of a vicious cycle:
Sulphate levels are low --> Intestinal defences are low --> Yeast
overgrowth --> Sulphur reducing bacteria --> Sulphate levels even lower
---> etc, etc

This might also account for sleeping difficulties..
M, do you know if your sulphate levels are ok ?

Sulfation is part of the Live Phase II Detox
Sulfation detoxifies phenols and amines, which are produced in the
body, *and in the gut* by bacteria, yeast and other fungi.
It also detoxifies *hormones* and chemicals..
It requires: Sulfate, phenol-sulfo-transferase enzyme (which is
dependent on sulfate)
It's tested by checking the conversion of paracetamol to its sulphate.

euthyroid.org/metabolism.html
>Sulfation of T4 has a dramatic effect on deiodination (Fig 1). IRD of T4 sulfate (T4S) and T3 sulfate (T3S) by D1 is approximately 200 and 40 times faster (respectively) than the IRD of the non-sulfated compounds whereas the ORD of T4S is completely blocked14. Sulfation is therefore a primary and critical step in the metabolism of thyroid hormones, when D1 activity is normal.

www.kuleuven.ac.be/bio/endo/periphery.htm
>Sulfation of thyroid hormones interacts with their deiodination, in such a way that sulfation facilitates the inactivation of thyroid hormones through D1 and thus offers an extra protection against too high concentrations of active hormone (T3). If sulfatases are present, sulfation can also be a manner to construct a reserve of sulfated T4 or T3, which can again be converted into active T3. This is important insituations, in which D1 activity is low, and D3 activity is high. From the preceeding, it is clear that when we want to study the regulation and the function of thyroid hormones, we cannot only limit ourselves to measuring the hormone concentrations in plasma, but we also need to pay attention to the deiodination and sulfation of thyroid hormones, their transport and the interaction with different receptors.

This study might be interesting too:
Sulfation of thyroid hormone and dopamine during human development:
ontogeny of phenol sulfotransferases and arylsulfatase in liver, lung,
an
brain.
www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11397879&form=6&
db=m&Dopt=r
(Remember: Cut and paste the entire address into the web browser)

A short overview of my mineral imbalanes. I decided to summarize them
so that perhaps it might ring a bell..

* Low sodium
* Low sulphate
* High potassium
* High calcium
* High copper

(Also low selenium, low manganese, low silicium)
(Still waiting for urine organic acid and urine amino acid test
results...)

Some unsorted references I found:
www.dancingstar.co.za/leakygut.htm
osiris.sunderland.ac.uk/autism/durham95.html
www.atsdr.cdc.gov/toxprofiles/phs115.html
www.rettsyndrome.org/digests/00069.htm
www.krysalis.net/autism.htm

Phenol Info
home.pacbell.net/cscomp/phenol.htm

Liver sulphation
www.loudzen.com/canary/study/detox.html

An interesting page on curing candida with a zapper:
www.ioa.com/~dragonfly/candida.html

Greetings from The Netherlands,

Ed





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