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How to interpret urine organic acid and urine amino acid test results ?
Wednesday, February 27 2002 - Filed under: General

Hi,

Today I finally received the results of the urine organic acid and urine amino acid tests:

It's four sheets full of test results..

I found some I can interpret myself:

++ 3-hydroxy butyric acid elevated at 47.7 (ref 0-10) mmol/mcr
++ acetoacetic acid elevated at 62.2 (ref 0-10) mmol/mcr

These are the ketone bodies..
Nice to see confirmed that I often am in ketosis (low carb diet)

-- Ascorbic acid is low at 3.91 (ref 10-200)
I'll supplement some more vitamin C.

Then I see that :

2-oxo-glutaric acid is very low at 0.50 (ref 15-200) mmol/mcr
This might mean that I have a glutathione deficiency.

home.vicnet.net.au/~mecfs/general/oxygen.html
www.cfs.inform.dk/Optimists/cheneyoxygen.txt
>Citrate
>is converted to 2-oxo-glutaric by an enzyme that is glutathione-dependent.
>So if glutathione is down, citrate will go up. And 2-oxo-glutaric will go
>down. That's in the citric acid cycle - an energy producing cycle.''

On the other hand, my citric acid levels aren't elevated, but intracellular it may be elevated..
If this is a problem, then my blood must be alkaline and my urine acid.
My urine is acid every morning at about pH 5.0...

The interpretation report says that many amino acids might be elevated or low because of B6 deficiency.
I was taking Solgar B-100 at that time (containing 100mg pyridoxine).
Then I learned that B6 (pyridoxine) is a precursor to pyridoxalphosphate, which is the actual enzyme that does the job in the metabolism of proteins.
I found a pyridoxalphosphate supplement and will use that soon..

A quote:
Three forms of B6: pyridoxine, pyridoxal, and pyridoxamine. All forms functional as precursors of pyridoxine coenzyme, pyridoxalphosphate (PLP). PLP very potent coenzyme.1,2

PLP is necessary for many protein metabolism reactions such as transfer of amino groups, removal of amide groups, removal of a carbon dioxide molecule from carboxylic acid, homocysteine conversion, niacin and serotonin formation from tryptophan, nicotinic acid formation, hemoglobin synthesis, and amino acid transport.1,2

Deficiency signs and symptoms include eczema, seborrheic dermatitis of ears, nose, mouth, glossitis angular stomatitis, and chapped lips.1
end quote

Pyridoxalphosphate is up to 10 times as powerful as normal B6 (pyridoxine)..

I'll write down the abnormal figures below:

-- 2-oxo-glutaric is very low at 0.50 (ref 15-200) mmol/mcr
Meaning: Low conversion of citric acid to 2-oxo-glutaric acid in the Kreb's cycle
Needed for conversion: B3, magnesium, manganese, iron and glutathione

++ Indican ++ (elevated)
This is a by-product of bacterial metabolism of the amino acid trytophan, and elevated levels may indicate overgrowth of the bowel.
www.healthy.net/library/books/textbook/section2/indic.pdf

Essential amino's that are elevated
------------------------------------------------------
++ valine is elevated at 78 (normal 10-55)
++ methionine is elevated at 71 (ref 10-60) (see Mg note)


Essential amino's that are low
------------------------------------------------------
Tryptophan levels are too low (is essential amino); Must be caused by same bacteria as above (Indican test)
-- Tryptophan slightly low at 26 (ref 30-140)


MAGNESIUM-related
Probable disturbed functioning of magnesium-dependant enzymes.
Mg. The following amino acids are elevated:
------------------------------------------------------
++ Fosfoserine high normal at 72 (20-90)
++ Methionine elevated at 71 (10-60)
++ Ethanolamine at 268 (80-350)


VITAMIN B6-related
Probable disturbed functioning of B6-dependent enzymes.
B6. The following amino's are elevated:
------------------------------------------------------
++ alfa-amino-adipic acid elevated at 127, ref 10-50 umol/24h (B6 related)
++ beta-alanine is elevated at 70 (ref 0-50)
Interpretation of elevated beta-alanine:
* Reduced need for B6
* Decreased reabsorption of amino acids in the kidneys, predominantly taurine (probably low anyway)
* Reduced breakdown of anserine and carnosine
* Disturbed intestinal flora


B6. The following amino's are low:
------------------------------------------------------
-- alfa-amino-butyric acid slightly low at 22 (normal 25-85) (B6 related)
-- cystathion at 18 (15-75)

++ gamma-amino-butyric acid elevated at 41 (normal 0-20)
Due to disturbed intestinal flora ?

++ hydroxylysine elevated at 23 (ref 0-15)
Catabolic proces ??

++ 1-methylhistidine very high at 906 (ref 130-390)
Probably due to defect in methylation process. Possibly because of B12/folic acid deficiency

++ 3-methylhistidine very high at 549 (ref 50-300)
Probably due to defect in methylation process. Possibly because of B12/folic acid deficiency
Might also be caused by high meat consumption

++ anserine elevated at 115 (ref 0-55)
Fits elevated beta-alanine or incomplete protein breakdown (anserine is a dipeptide that consists of B-alanine and methylhistidine)

++ carnosine very high at 324 (ref 0-100)
Fits elevated b-alanine and histidine

-- glutamic acid lactam low at 10.5 (ref 20-115) mmol/mcr
Metabolite of glutathione. Glutathione probably low.

-- Fumaric acid low at 0.19 (0-10)
What does this mean ?
Can be increased with b1,b2,b3,b5,lipoic acid, coQ10 and magnesium

Neurotransmitters
-----------------
-- VMA vanylmandelate low at 1.47 (0-18)
-- HVA homovanillate low at 0.92 (0-25)
These are metabolites of the catecholamines, epinephrine and
norepinephrine, which are based on the essential amino's fenylalanine
and tyrosine. Possible symptoms are depression, insomnia, incapability
to handle stress

So, summarizing there are three reasons to think that the intestinal
flora isn't ok yet:
++ indican test positive
++ beta alanine elevated
++ gamma amino butyric acid elevated
-- tryptophan low

The advice is the following:
* Tryptophan supplement 0.5-1.5 gram/day
* L-taurine supplement 0.5-1.5 gram/day
* glutathione supplement 0.1-0.3 gram/day (useless I guess, not
absorbed)
* alpha-ketoglutaric acid 0.5-1.5 gram/day
* alpha-lipoic acid 100-300 mg/day

I already do the following
* coenzym Q10 10-20 mg/day
* magnesium 200-400mg/day elemental
* manganese 10-20mg/day
* All B-vitamins in high doses
* Vitamin C 3 grams a day

------------------------------------------

Pfew.. That's a whole lot of info to digest.
I hope some of you can get me some advice..

Thanks,

Ed,
The Netherlands





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